Structure of penicillin-binding protein A from M. tuberculosis: imipenem acyl-enzyme complex

Summary for 3UPN

Related3LO7 3UN7 3UPO 3UPP
DescriptorPenicillin-binding protein A, (5R)-5-[(1S,2R)-1-formyl-2-hydroxypropyl]-3-[(2-{[(E)-iminomethyl]amino}ethyl)sulfanyl]-4,5-dihydro-1H-pyrrole-2-carboxylic acid (3 entities in total)
Functional Keywordstranspeptidase, peptidoglycan, beta-lactam, penicillin-binding protein-antibiotic complex, penicillin-binding protein/antibiotic
Biological sourceMycobacterium tuberculosis
Cellular locationCell membrane; Single-pass type II membrane protein (Probable) P71586
Total number of polymer chains2
Total molecular weight97531.71
Davies, C.,Fedorovich, A. (deposition date: 2011-11-18, release date: 2012-10-24)
Primary citation
Fedarovich, A.,Nicholas, R.A.,Davies, C.
The role of the beta5-alpha11 loop in the active-site dynamics of acylated penicillin-binding protein A from Mycobacterium tuberculosis
J.Mol.Biol., 418:316-330, 2012
PubMed: 22365933 (PDB entries with the same primary citation)
DOI: 10.1016/j.jmb.2012.02.021
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.256403.9%6.1%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution