3UPN

Structure of penicillin-binding protein A from M. tuberculosis: imipenem acyl-enzyme complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0008360	biological_process	regulation of cell shape
A	0008658	molecular_function	penicillin binding
A	0009002	molecular_function	serine-type D-Ala-D-Ala carboxypeptidase activity
A	0009252	biological_process	peptidoglycan biosynthetic process
A	0016787	molecular_function	hydrolase activity
A	0031504	biological_process	peptidoglycan-based cell wall organization
A	0071555	biological_process	cell wall organization
A	0071972	molecular_function	peptidoglycan L,D-transpeptidase activity
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0008360	biological_process	regulation of cell shape
B	0008658	molecular_function	penicillin binding
B	0009002	molecular_function	serine-type D-Ala-D-Ala carboxypeptidase activity
B	0009252	biological_process	peptidoglycan biosynthetic process
B	0016787	molecular_function	hydrolase activity
B	0031504	biological_process	peptidoglycan-based cell wall organization
B	0071555	biological_process	cell wall organization
B	0071972	molecular_function	peptidoglycan L,D-transpeptidase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	BINDING SITE FOR RESIDUE IM2 A 800

Chain	Residue
A	GLY221
A	HOH920
A	SER222
A	SER281
A	ASN283
A	GLN411
A	THR425
A	GLY426
A	THR427
A	ALA473

---

site_id	AC2
Number of Residues	11
Details	BINDING SITE FOR RESIDUE IM2 B 800

Chain	Residue
B	SER222
B	SER281
B	ASN283
B	LYS424
B	THR425
B	GLY426
B	THR427
B	ALA441
B	ASP465
B	GLY471
B	ALA473

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Active site: {"description":"Acyl-ester intermediate","evidences":[{"source":"UniProtKB","id":"P0AD65","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---