3UPJ

HUMAN IMMUNODEFICIENCY VIRUS TYPE 2 PROTEASE MUTANT WITH LYS 57 REPLACED BY LEU (K57L) COMPLEX WITH U096333 [4-HYDROXY-3-[1-(PHENYL)PROPYL]-7-METHOXYCOUMARIN]

Summary for 3UPJ

• Entry DOI: 10.2210/pdb3upj/pdb
• Descriptor: HIV-2 PROTEASE, 4-HYDROXY-7-METHOXY-3-(1-PHENYL-PROPYL)-CHROMEN-2-ONE (3 entities in total)
• Functional Keywords: hydrolase (acid protease)
• Biological source: Human immunodeficiency virus 2
• Cellular location: Gag-Pol polyprotein: Host cell membrane; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P04584
• Total number of polymer chains: 2
• Total formula weight: 21734.97

Authors

Watenpaugh, K.D.,Mulichak, A.M.,Janakiraman, M.N. (deposition date: 1996-03-04, release date: 1996-10-14, Last modification date: 2024-04-03)

• Primary citation: Thaisrivongs, S.,Watenpaugh, K.D.,Howe, W.J.,Tomich, P.K.,Dolak, L.A.,Chong, K.-T.,Tomich, C.-S.C.,Tomasselli, A.G.,Turner, S.R.,Strohbach, J.W.,Mulichak, A.M.,Janakiraman, M.N.,Moon, J.B.,Lynn, J.C.,Horng, M.-M.,Hinshaw, R.R.,Curry, K.A.,Rothrock, D.J.; Structure-based design of novel HIV protease inhibitors: carboxamide-containing 4-hydroxycoumarins and 4-hydroxy-2-pyrones as potent nonpeptidic inhibitors.; J.Med.Chem., 38:3624-3637, 1995; PubMed: 7658450; DOI: 10.1021/jm00018a023

Experimental method

X-RAY DIFFRACTION (2.5 Å)