3UMK
X-ray structure of the E2 domain of the human amyloid precursor protein (APP) in complex with copper
Summary for 3UMK
Entry DOI | 10.2210/pdb3umk/pdb |
Related | 3UMH 3UMI |
Descriptor | Amyloid beta A4 protein, ACETATE ION, COPPER (II) ION, ... (5 entities in total) |
Functional Keywords | metal binding site, metal binding, cell surface, secretory pathway, metal binding protein |
Biological source | Homo sapiens (human) |
Cellular location | Membrane; Single-pass type I membrane protein: P05067 |
Total number of polymer chains | 1 |
Total formula weight | 26035.41 |
Authors | Dahms, S.O.,Konnig, I.,Roeser, D.,Guhrs, K.H.,Than, M.E. (deposition date: 2011-11-13, release date: 2012-01-25, Last modification date: 2024-02-28) |
Primary citation | Dahms, S.O.,Konnig, I.,Roeser, D.,Guhrs, K.H.,Mayer, M.C.,Kaden, D.,Multhaup, G.,Than, M.E. Metal Binding Dictates Conformation and Function of the Amyloid Precursor Protein (APP) E2 Domain. J.Mol.Biol., 416:438-452, 2012 Cited by PubMed: 22245578DOI: 10.1016/j.jmb.2011.12.057 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
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