3UKB

(R)-cEt-BNA decamer structure

Summary for 3UKB

• Entry DOI: 10.2210/pdb3ukb/pdb
• Related: 3UKC 3UKE
• Descriptor: DNA (5'-D(*GP*CP*GP*TP*AP*(RCE)P*AP*CP*GP*C)-3') (2 entities in total)
• Functional Keywords: a-form dna, bicyclic nucleic acid, bna, dna, cet-bna, antisense oligonucleotides
• Total number of polymer chains: 2
• Total formula weight: 6146.03

Authors

Pallan, P.S.,Egli, M. (deposition date: 2011-11-09, release date: 2012-06-20, Last modification date: 2023-09-13)

Primary citation

Pallan, P.S.,Allerson, C.R.,Berdeja, A.,Seth, P.P.,Swayze, E.E.,Prakash, T.P.,Egli, M.
Structure and nuclease resistance of 2',4'-constrained 2'-O-methoxyethyl (cMOE) and 2'-O-ethyl (cEt) modified DNAs.
Chem.Commun.(Camb.), 48:8195-8197, 2012

PubMed Abstract: Combining the structural elements of the second generation 2'-O-methoxyethyl (MOE) and locked nucleic acid (LNA) antisense oligonucleotide (AON) modifications yielded the highly nuclease resistant 2',4'-constrained MOE and ethyl bicyclic nucleic acids (cMOE and cEt BNA, respectively). Crystal structures of DNAs with cMOE or cEt BNA residues reveal their conformational preferences. Comparisons with MOE and LNA structures allow insights into their favourable properties for AON applications.

PubMed: 22614180
DOI: 10.1039/c2cc32286b

Experimental method

X-RAY DIFFRACTION (1.42 Å)