3UJM
Crystal structure of the NTF2-like domain of the Drosophila melanogaster Rasputin protein
Summary for 3UJM
| Entry DOI | 10.2210/pdb3ujm/pdb |
| Descriptor | Rasputin, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID (3 entities in total) |
| Functional Keywords | ntf2-like fold, ras signaling, signaling protein |
| Biological source | Drosophila melanogaster (Fruit fly) |
| Total number of polymer chains | 2 |
| Total formula weight | 28241.70 |
| Authors | Vognsen, T.,Kristensen, O. (deposition date: 2011-11-08, release date: 2012-04-25, Last modification date: 2023-09-13) |
| Primary citation | Vognsen, T.,Kristensen, O. Crystal structure of the Rasputin NTF2-like domain from Drosophila melanogaster. Biochem.Biophys.Res.Commun., 420:188-192, 2012 Cited by PubMed Abstract: The crystal structure of the NTF2-like domain of the Drosophila homolog of Ras GTPase SH3 Binding Protein (G3BP), Rasputin, was determined at 2.7Å resolution. The overall structure is highly similar to nuclear transport factor 2: It is a homodimer comprised of a β-sheet and three α-helices forming a cone-like shape. However, known binding sites for RanGDP and FxFG containing peptides show electrostatic and steric differences compared to nuclear transport factor 2. A HEPES molecule bound in the structure suggests a new, and possibly physiologically relevant, ligand binding site. PubMed: 22414690DOI: 10.1016/j.bbrc.2012.02.140 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.741 Å) |
Structure validation
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