3UIC

Crystal Structure of FabI, an Enoyl Reductase from F. tularensis, in complex with a Novel and Potent Inhibitor

3UIC の概要

• エントリーDOI: 10.2210/pdb3uic/pdb
• 分子名称: Enoyl-[acyl-carrier-protein] reductase [NADH], NICOTINAMIDE-ADENINE-DINUCLEOTIDE, 1-(3,4-dichlorobenzyl)-5,6-dimethyl-1H-benzimidazole, ... (4 entities in total)
• 機能のキーワード: rossmann fold, enoyl reductase, nadh binding, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• 由来する生物種: Francisella tularensis subsp. tularensis
• タンパク質・核酸の鎖数: 16
• 化学式量合計: 495603.01

構造登録者

Mehboob, S.,Santarsiero, B.D.,Truong, K.,Johnson, M.E. (登録日: 2011-11-04, 公開日: 2012-06-06, 最終更新日: 2023-09-13)

• 主引用文献: Mehboob, S.,Hevener, K.E.,Truong, K.,Boci, T.,Santarsiero, B.D.,Johnson, M.E.; Structural and enzymatic analyses reveal the binding mode of a novel series of Francisella tularensis enoyl reductase (FabI) inhibitors.; J.Med.Chem., 55:5933-5941, 2012; PubMed: 22642319; DOI: 10.1021/jm300489v

実験手法

X-RAY DIFFRACTION (2.5 Å)