3UHM

UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase in complex with inhibitor

3UHM の概要

• エントリーDOI: 10.2210/pdb3uhm/pdb
• 関連するPDBエントリー: 3U1Y
• 分子名称: UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase, ZINC ION, (2R)-N-hydroxy-2-methyl-2-(methylsulfonyl)-4-(2-oxo-4-phenylpyridin-1(2H)-yl)butanamide, ... (6 entities in total)
• 機能のキーワード: amidohydrolases, anti-bacterial agents, bacteria, catalytic domain, drug design, enzyme inhibitors, gram negative, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Pseudomonas aeruginosa
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 33697.58

構造登録者

Montgomery, J.,Liu, S. (登録日: 2011-11-03, 公開日: 2012-02-01, 最終更新日: 2023-09-13)

• 主引用文献: Montgomery, J.I.,Brown, M.F.,Reilly, U.,Price, L.M.,Abramite, J.A.,Arcari, J.,Barham, R.,Che, Y.,Chen, J.M.,Chung, S.W.,Collantes, E.M.,Desbonnet, C.,Doroski, M.,Doty, J.,Engtrakul, J.J.,Harris, T.M.,Huband, M.,Knafels, J.D.,Leach, K.L.,Liu, S.,Marfat, A.,McAllister, L.,McElroy, E.,Menard, C.A.,Mitton-Fry, M.,Mullins, L.,Noe, M.C.,O'Donnell, J.,Oliver, R.,Penzien, J.,Plummer, M.,Shanmugasundaram, V.,Thoma, C.,Tomaras, A.P.,Uccello, D.P.,Vaz, A.,Wishka, D.G.; Pyridone methylsulfone hydroxamate LpxC inhibitors for the treatment of serious gram-negative infections.; J.Med.Chem., 55:1662-1670, 2012; PubMed: 22257165; DOI: 10.1021/jm2014875

実験手法

X-RAY DIFFRACTION (1.26 Å)