3UG8

AKR1C3 complex with indomethacin at pH 7.5

Summary for 3UG8

Entry DOI	10.2210/pdb3ug8/pdb
Related	1S2A 3UFY 3UGR
Descriptor	Aldo-keto reductase family 1 member C3, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, INDOMETHACIN, ... (5 entities in total)
Functional Keywords	tim barrel, oxidoreductase, many small molecules, hormones, prostaglandins
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: P42330
Total number of polymer chains	1
Total formula weight	39140.63
Authors	Flanagan, J.U.,Yosaatmadja, Y.,Teague, R.M.,Chai, M.,Squire, C.J. (deposition date: 2011-11-02, release date: 2012-08-15, Last modification date: 2023-11-01)
Primary citation	Flanagan, J.U.,Yosaatmadja, Y.,Teague, R.M.,Chai, M.Z.,Turnbull, A.P.,Squire, C.J. Crystal structures of three classes of non-steroidal anti-inflammatory drugs in complex with aldo-keto reductase 1C3. Plos One, 7:e43965-e43965, 2012 Cited by PubMed: 22937138 DOI: 10.1371/journal.pone.0043965 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.73 Å)

Structure validation