3UE8

Kynurenine Aminotransferase II Inhibitors

Summary for 3UE8

• Entry DOI: 10.2210/pdb3ue8/pdb
• Descriptor: Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial, (5-hydroxy-4-{[(1-hydroxy-2-oxo-1,2-dihydroquinolin-3-yl)amino]methyl}-6-methylpyridin-3-yl)methyl dihydrogen phosphate, CHLORIDE ION (3 entities in total)
• Functional Keywords: kat ii, kynurenine aminotransferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Mitochondrion : Q8N5Z0
• Total number of polymer chains: 2
• Total formula weight: 99050.14

Authors

Dounay, A.B.,Anderson, M.,Bechle, B.M.,Campbell, B.M.,Claffey, M.M.,Evdokimov, A.,Edelweiss, E.,Fonseca, K.R.,Gan, X.,Ghosh, S.,Hayward, M.M.,Horner, W.,Kim, J.Y.,McAllister, L.A.,Pandit, J.,Paradis, V.,Parikh, V.D.,Reese, M.R.,Rong, S.B.,Salafia, M.A.,Schuyten, K.,Strick, C.A.,Tuttle, J.B.,Valentine, J.,Wang, H.,Zawadzke, L.E.,Verhoest, P.R. (deposition date: 2011-10-28, release date: 2012-02-01, Last modification date: 2024-02-28)

• Primary citation: Dounay, A.B.,Anderson, M.,Bechle, B.M.,Campbell, B.M.,Claffey, M.M.,Evdokimov, A.,Evrard, E.,Fonseca, K.R.,Gan, X.,Ghosh, S.,Hayward, M.M.,Horner, W.,Kim, J.Y.,McAllister, L.A.,Pandit, J.,Paradis, V.,Parikh, V.D.,Reese, M.R.,Rong, S.,Salafia, M.A.,Schuyten, K.,Strick, C.A.,Tuttle, J.B.,Valentine, J.,Wang, H.,Zawadzke, L.E.,Verhoest, P.R.; Discovery of Brain-Penetrant, Irreversible Kynurenine Aminotransferase II Inhibitors for Schizophrenia.; ACS Med Chem Lett, 3:187-192, 2012; PubMed: 24900455; DOI: 10.1021/ml200204m

Experimental method

X-RAY DIFFRACTION (3.22 Å)