3UE1

Crystal strucuture of Acinetobacter baumanni PBP1A in complex with MC-1

Summary for 3UE1

• Entry DOI: 10.2210/pdb3ue1/pdb
• Related: 3UDF 3UDI 3UDX 3UE0 3UE3
• Descriptor: Penicillin-binding protein 1a, (4S,7Z)-7-(2-amino-1,3-thiazol-4-yl)-1-[({4-[(2R)-2,3-dihydroxypropyl]-3-(4,5-dihydroxypyridin-2-yl)-5-oxo-4,5-dihydro- 1H-1,2,4-triazol-1-yl}sulfonyl)amino]-4-formyl-10,10-dimethyl-1,6-dioxo-9-oxa-2,5,8-triazaundec-7-en-11-oate (3 entities in total)
• Functional Keywords: transglycosylase, transpeptidase, penicillin-binding protein-antibiotic complex, penicillin-binding protein/antibiotic
• Biological source: Acinetobacter baumannii
• Total number of polymer chains: 2
• Total formula weight: 165205.10

Authors

Han, S. (deposition date: 2011-10-28, release date: 2011-12-14, Last modification date: 2024-03-06)

• Primary citation: Han, S.,Caspers, N.,Zaniewski, R.P.,Lacey, B.M.,Tomaras, A.P.,Feng, X.,Geoghegan, K.F.,Shanmugasundaram, V.; Distinctive attributes of beta-lactam target proteins in Acinetobacter baumannii relevant to development of new antibiotics; J.Am.Chem.Soc., 133:20536-20545, 2011; PubMed: 22050378; DOI: 10.1021/ja208835z

Experimental method

X-RAY DIFFRACTION (2.73 Å)