3UDD

Tankyrase-1 in complex with small molecule inhibitor

Summary for 3UDD

Entry DOI	10.2210/pdb3udd/pdb
Descriptor	Tankyrase-1, ZINC ION, 3-(4-methoxyphenyl)-5-({[4-(4-methoxyphenyl)-5-methyl-4H-1,2,4-triazol-3-yl]sulfanyl}methyl)-1,2,4-oxadiazole, ... (6 entities in total)
Functional Keywords	transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: O95271
Total number of polymer chains	2
Total formula weight	52713.92
Authors	Kirby, C.A.,Stams, T. (deposition date: 2011-10-28, release date: 2012-02-01, Last modification date: 2024-02-28)
Primary citation	Shultz, M.D.,Kirby, C.A.,Stams, T.,Chin, D.N.,Blank, J.,Charlat, O.,Cheng, H.,Cheung, A.,Cong, F.,Feng, Y.,Fortin, P.D.,Hood, T.,Tyagi, V.,Xu, M.,Zhang, B.,Shao, W. [1,2,4]triazol-3-ylsulfanylmethyl)-3-phenyl-[1,2,4]oxadiazoles: antagonists of the Wnt pathway that inhibit tankyrases 1 and 2 via novel adenosine pocket binding. J.Med.Chem., 55:1127-1136, 2012 Cited by PubMed: 22260203 DOI: 10.1021/jm2011222 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.95 Å)

Structure validation