3UAN

Crystal structure of 3-O-sulfotransferase (3-OST-1) with bound PAP and heptasaccharide substrate

3UAN の概要

• エントリーDOI: 10.2210/pdb3uan/pdb
• 関連するPDBエントリー: 1T8T 1T8U 1ZRH
• 分子名称: Heparan sulfate glucosamine 3-O-sulfotransferase 1, 2-acetamido-2-deoxy-6-O-sulfo-alpha-D-glucopyranose-(1-4)-beta-D-glucopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-beta-D-glucopyranuronic acid, 2-acetamido-2-deoxy-6-O-sulfo-alpha-D-glucopyranose-(1-4)-beta-D-glucopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose, ... (6 entities in total)
• 機能のキーワード: sulfotransferase, heparan sulfate, alpha/beta motif, co-factor paps/pap, heparan sulfate oligosaccharides, golgi-localized, transferase
• 由来する生物種: Mus musculus (mouse)
• 細胞内の位置: Golgi apparatus lumen (Probable): O35310
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 66784.72

構造登録者

Moon, A.F.,Xu, Y.,Woody, S.M.,Krahn, J.M.,Linhardt, R.J.,Liu, J.,Pedersen, L.C. (登録日: 2011-10-21, 公開日: 2012-04-04, 最終更新日: 2023-09-13)

• 主引用文献: Moon, A.F.,Xu, Y.,Woody, S.M.,Krahn, J.M.,Linhardt, R.J.,Liu, J.,Pedersen, L.C.; Dissecting the substrate recognition of 3-O-sulfotransferase for the biosynthesis of anticoagulant heparin.; Proc.Natl.Acad.Sci.USA, 109:5265-5270, 2012; PubMed: 22431632; DOI: 10.1073/pnas.1117923109

実験手法

X-RAY DIFFRACTION (1.844 Å)