3U8Z
human merlin FERM domain
Summary for 3U8Z
Entry DOI | 10.2210/pdb3u8z/pdb |
Descriptor | Merlin (2 entities in total) |
Functional Keywords | neurofibromatosis, tumor suppressor, signaling protein |
Biological source | Homo sapiens (human) |
Cellular location | Isoform 1: Cell projection, filopodium membrane; Peripheral membrane protein; Cytoplasmic side. Isoform 7: Cytoplasm, perinuclear region. Isoform 9: Cytoplasm, perinuclear region. Isoform 10: Nucleus: P35240 |
Total number of polymer chains | 4 |
Total formula weight | 141775.83 |
Authors | Yogesha, S.D.,Sharff, A.J.,Giovannini, M.,Bricogne, G.,Izard, T. (deposition date: 2011-10-17, release date: 2011-11-02, Last modification date: 2023-09-13) |
Primary citation | Yogesha, S.D.,Sharff, A.J.,Giovannini, M.,Bricogne, G.,Izard, T. Unfurling of the band 4.1, ezrin, radixin, moesin (FERM) domain of the merlin tumor suppressor. Protein Sci., 20:2113-2120, 2011 Cited by PubMed: 22012890DOI: 10.1002/pro.751 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.64 Å) |
Structure validation
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