3U8K
Crystal structure of the acetylcholine binding protein (AChBP) from Lymnaea stagnalis in complex with NS3573 (1-(5-ethoxypyridin-3-yl)-1,4-diazepane)
Summary for 3U8K
Entry DOI | 10.2210/pdb3u8k/pdb |
Related | 1UV6 1UW6 3U8J 3U8L 3U8M 3U8N |
Descriptor | Acetylcholine-binding protein, 1-(5-ethoxypyridin-3-yl)-1,4-diazepane, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total) |
Functional Keywords | lymnaea stagnalis, agonist, ligand-bindig domain, acetylcholine, acetylcholine-binding protein, acetylcholine-binding protein-agonist complex, acetylcholine-binding protein/agonist |
Biological source | Lymnaea stagnalis (Great pond snail) |
Cellular location | Secreted: P58154 |
Total number of polymer chains | 20 |
Total formula weight | 483300.69 |
Authors | Rohde, L.A.H.,Ahring, P.K.,Jensen, M.L.,Nielsen, E.O.,Peters, D.,Helgstrand, C.,Krintel, C.,Harpsoe, K.,Gajhede, M.,Kastrup, J.S.,Balle, T. (deposition date: 2011-10-17, release date: 2011-12-14, Last modification date: 2023-09-13) |
Primary citation | Rohde, L.A.,Ahring, P.K.,Jensen, M.L.,Nielsen, E.,Peters, D.,Helgstrand, C.,Krintel, C.,Harpse, K.,Gajhede, M.,Kastrup, J.S.,Balle, T. Intersubunit bridge formation governs agonist efficacy at nicotinic acetylcholine alpha 4 beta 2 receptors: unique role of halogen bonding revealed. J.Biol.Chem., 287:4248-4259, 2012 Cited by PubMed: 22170047DOI: 10.1074/jbc.M111.292243 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.47 Å) |
Structure validation
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