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3U81

Crystal structure of a SAH-bound semi-holo form of rat Catechol-O-methyltransferase

Summary for 3U81
Entry DOI10.2210/pdb3u81/pdb
Related3nwb 3nwe 3r6t 3s68
DescriptorCatechol O-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE, POTASSIUM ION, ... (4 entities in total)
Functional Keywordsmethyltransferase, neurotransmitter degradation, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceRattus norvegicus (rat)
Cellular locationIsoform 2: Cytoplasm. Isoform 1: Cell membrane; Single-pass type II membrane protein; Extracellular side: P22734
Total number of polymer chains1
Total formula weight25117.84
Authors
Ehler, A.,Schlatter, D.,Stihle, M.,Benz, J.,Rudolph, M.G. (deposition date: 2011-10-15, release date: 2012-02-01, Last modification date: 2024-02-28)
Primary citationEllermann, M.,Lerner, C.,Burgy, G.,Ehler, A.,Bissantz, C.,Jakob-Roetne, R.,Paulini, R.,Allemann, O.,Tissot, H.,Grunstein, D.,Stihle, M.,Diederich, F.,Rudolph, M.G.
Catechol-O-methyltransferase in complex with substituted 3'-deoxyribose bisubstrate inhibitors.
Acta Crystallogr.,Sect.D, 68:253-260, 2012
Cited by
PubMed: 22349227
DOI: 10.1107/S0907444912001138
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.13 Å)
Structure validation

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