3U7D

Crystal structure of the KRIT1/CCM1 FERM domain in complex with the heart of glass (HEG1) cytoplasmic tail

3U7D の概要

• エントリーDOI: 10.2210/pdb3u7d/pdb
• 分子名称: Krev interaction trapped protein 1, Protein HEG homolog 1 (3 entities in total)
• 機能のキーワード: psi-biology, assembly, dynamics and evolution of cell-cell and cell-matrix adhesions, cellmat, ferm domain, rap1 effector, membrane protein cytoplasmic tail, protein binding, structural genomics
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Cytoplasm, cytoskeleton: O00522; Isoform 1: Cell membrane; Single-pass type I membrane protein (Potential). Isoform 2: Secreted (Potential): Q9ULI3
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 81085.61

構造登録者

Gingras, A.R.,Liu, J.J.,Ginsberg, M.H.,Assembly, Dynamics and Evolution of Cell-Cell and Cell-Matrix Adhesions (CELLMAT) (登録日: 2011-10-13, 公開日: 2012-09-12, 最終更新日: 2024-02-28)

• 主引用文献: Gingras, A.R.,Liu, J.J.,Ginsberg, M.H.; Structural basis of the junctional anchorage of the cerebral cavernous malformations complex.; J.Cell Biol., 199:39-48, 2012; PubMed: 23007647; DOI: 10.1083/jcb.201205109

実験手法

X-RAY DIFFRACTION (2.49 Å)