3U5L

Crystal Structure of the first bromodomain of human BRD4 in complex with a benzo-triazepine ligand (BzT-7)

3U5L の概要

• エントリーDOI: 10.2210/pdb3u5l/pdb
• 関連するPDBエントリー: 3U5J 3U5K
• 分子名称: Bromodomain-containing protein 4, 1,2-ETHANEDIOL, 8-chloro-1,4-dimethyl-6-phenyl-4H-[1,2,4]triazolo[4,3-a][1,3,4]benzotriazepine, ... (4 entities in total)
• 機能のキーワード: bromodomain-containing protein 4 isoform long, brd4, bromodomain containing protein 4, cap, hunk1, mcap, mitotic chromosome associated protein, structural genomics consortium, sgc, signaling protein-inhibitor complex, signaling protein/inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Nucleus (By similarity): O60885
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 15485.23

構造登録者

Filippakopoulos, P.,Picaud, S.,Felletar, I.,Fedorov, O.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Weigelt, J.,Bountra, C.,Bracher, F.,Knapp, S.,Structural Genomics Consortium (SGC) (登録日: 2011-10-11, 公開日: 2011-11-23, 最終更新日: 2023-09-13)

• 主引用文献: Filippakopoulos, P.,Picaud, S.,Fedorov, O.,Keller, M.,Wrobel, M.,Morgenstern, O.,Bracher, F.,Knapp, S.; Benzodiazepines and benzotriazepines as protein interaction inhibitors targeting bromodomains of the BET family.; Bioorg.Med.Chem., 20:1878-1886, 2012; PubMed: 22137933; DOI: 10.1016/j.bmc.2011.10.080

実験手法

X-RAY DIFFRACTION (1.39 Å)