3U2Q
EF-Tu (Escherichia coli) in complex with NVP-LFF571
Summary for 3U2Q
Entry DOI | 10.2210/pdb3u2q/pdb |
Related | 3U6B 3U6K |
Related PRD ID | PRD_001072 |
Descriptor | Elongation factor Tu 1, Thiocillin GE2270 analogue NVP-LFF571, GUANOSINE-5'-DIPHOSPHATE, ... (5 entities in total) |
Functional Keywords | translation factor-antibiotic complex, translation factor/antibiotic |
Biological source | Escherichia coli |
Cellular location | Cytoplasm: P0CE47 Secreted: Q7M0J8 |
Total number of polymer chains | 2 |
Total formula weight | 45335.74 |
Authors | Palestrant, D.J. (deposition date: 2011-10-04, release date: 2012-05-02, Last modification date: 2023-11-15) |
Primary citation | LaMarche, M.J.,Leeds, J.A.,Amaral, A.,Brewer, J.T.,Bushell, S.M.,Deng, G.,Dewhurst, J.M.,Ding, J.,Dzink-Fox, J.,Gamber, G.,Jain, A.,Lee, K.,Lee, L.,Lister, T.,McKenney, D.,Mullin, S.,Osborne, C.,Palestrant, D.,Patane, M.A.,Rann, E.M.,Sachdeva, M.,Shao, J.,Tiamfook, S.,Trzasko, A.,Whitehead, L.,Yifru, A.,Yu, D.,Yan, W.,Zhu, Q. Discovery of LFF571: an investigational agent for Clostridium difficile infection. J.Med.Chem., 55:2376-2387, 2012 Cited by PubMed: 22315981DOI: 10.1021/jm201685h PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.7 Å) |
Structure validation
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