3U1Y

Potent Inhibitors of LpxC for the Treatment of Gram-Negative Infections

Summary for 3U1Y

• Entry DOI: 10.2210/pdb3u1y/pdb
• Descriptor: UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase, ZINC ION, (2R)-N-hydroxy-2-methyl-2-(methylsulfonyl)-4-{4'-[3-(morpholin-4-yl)propoxy]biphenyl-4-yl}butanamide, ... (4 entities in total)
• Functional Keywords: pseudomonas aeruginosa, lpxc, gram negative, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Pseudomonas aeruginosa
• Total number of polymer chains: 2
• Total formula weight: 67470.68

Authors

Brown, M.,Abramite, J.,Liu, S. (deposition date: 2011-09-30, release date: 2012-01-04, Last modification date: 2023-09-13)

Primary citation

Brown, M.F.,Reilly, U.,Abramite, J.A.,Arcari, J.T.,Oliver, R.,Barham, R.A.,Che, Y.,Chen, J.M.,Collantes, E.M.,Chung, S.W.,Desbonnet, C.,Doty, J.,Doroski, M.,Engtrakul, J.J.,Harris, T.M.,Huband, M.,Knafels, J.D.,Leach, K.L.,Liu, S.,Marfat, A.,Marra, A.,McElroy, E.,Melnick, M.,Menard, C.A.,Montgomery, J.I.,Mullins, L.,Noe, M.C.,O'Donnell, J.,Penzien, J.,Plummer, M.S.,Price, L.M.,Shanmugasundaram, V.,Thoma, C.,Uccello, D.P.,Warmus, J.S.,Wishka, D.G.
Potent inhibitors of LpxC for the treatment of Gram-negative infections.
J.Med.Chem., 55:914-923, 2012

PubMed Abstract: In this paper, we present the synthesis and SAR as well as selectivity, pharmacokinetic, and infection model data for representative analogues of a novel series of potent antibacterial LpxC inhibitors represented by hydroxamic acid.

PubMed: 22175825
DOI: 10.1021/jm2014748

Experimental method

X-RAY DIFFRACTION (2 Å)