3U1Y

Potent Inhibitors of LpxC for the Treatment of Gram-Negative Infections

3U1Y の概要

• エントリーDOI: 10.2210/pdb3u1y/pdb
• 分子名称: UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase, ZINC ION, (2R)-N-hydroxy-2-methyl-2-(methylsulfonyl)-4-{4'-[3-(morpholin-4-yl)propoxy]biphenyl-4-yl}butanamide, ... (4 entities in total)
• 機能のキーワード: pseudomonas aeruginosa, lpxc, gram negative, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Pseudomonas aeruginosa
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 67470.68

構造登録者

Brown, M.,Abramite, J.,Liu, S. (登録日: 2011-09-30, 公開日: 2012-01-04, 最終更新日: 2023-09-13)

主引用文献

Brown, M.F.,Reilly, U.,Abramite, J.A.,Arcari, J.T.,Oliver, R.,Barham, R.A.,Che, Y.,Chen, J.M.,Collantes, E.M.,Chung, S.W.,Desbonnet, C.,Doty, J.,Doroski, M.,Engtrakul, J.J.,Harris, T.M.,Huband, M.,Knafels, J.D.,Leach, K.L.,Liu, S.,Marfat, A.,Marra, A.,McElroy, E.,Melnick, M.,Menard, C.A.,Montgomery, J.I.,Mullins, L.,Noe, M.C.,O'Donnell, J.,Penzien, J.,Plummer, M.S.,Price, L.M.,Shanmugasundaram, V.,Thoma, C.,Uccello, D.P.,Warmus, J.S.,Wishka, D.G.
Potent inhibitors of LpxC for the treatment of Gram-negative infections.
J.Med.Chem., 55:914-923, 2012

PubMed Abstract: In this paper, we present the synthesis and SAR as well as selectivity, pharmacokinetic, and infection model data for representative analogues of a novel series of potent antibacterial LpxC inhibitors represented by hydroxamic acid.

PubMed: 22175825
DOI: 10.1021/jm2014748

実験手法

X-RAY DIFFRACTION (2 Å)