3U0S

Crystal Structure of an Enzyme Redesigned Through Multiplayer Online Gaming: CE6

3U0S の概要

• エントリーDOI: 10.2210/pdb3u0s/pdb
• 関連するPDBエントリー: 1E1A 3I1C
• 分子名称: Diisopropyl-fluorophosphatase, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, GLYCEROL, ... (6 entities in total)
• 機能のキーワード: protein engineering, computer-aided design, computationally-directed design, multiplayer online gaming, crowdsourcing, foldit, diels-alder, enzyme design, active site redesign, substrate specificity, beta-propeller, helix-loop-helix, loop remodel, hydrolase, de novo protein
• 由来する生物種: Loligo vulgaris (Common European squid)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 76536.43

構造登録者

Bale, J.B.,Shen, B.W.,Stoddard, B.L. (登録日: 2011-09-29, 公開日: 2012-02-01, 最終更新日: 2024-02-28)

• 主引用文献: Eiben, C.B.,Siegel, J.B.,Bale, J.B.,Cooper, S.,Khatib, F.,Shen, B.W.,Players, F.,Stoddard, B.L.,Popovic, Z.,Baker, D.; Increased Diels-Alderase activity through backbone remodeling guided by Foldit players.; Nat.Biotechnol., 30:190-192, 2012; PubMed: 22267011; DOI: 10.1038/nbt.2109

実験手法

X-RAY DIFFRACTION (2.6 Å)