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3TZB

Quinone Oxidoreductase (NQ02) bound to NSC13000

Summary for 3TZB
Entry DOI10.2210/pdb3tzb/pdb
DescriptorRibosyldihydronicotinamide dehydrogenase [quinone], ZINC ION, FLAVIN-ADENINE DINUCLEOTIDE, ... (5 entities in total)
Functional Keywordsoxidoreductase, fad
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm: P16083
Total number of polymer chains4
Total formula weight107594.41
Authors
Dunstan, M.S.,Leys, D. (deposition date: 2011-09-27, release date: 2011-11-02, Last modification date: 2024-02-28)
Primary citationNolan, K.A.,Dunstan, M.S.,Caraher, M.C.,Scott, K.A.,Leys, D.,Stratford, I.J.
In silico screening reveals structurally diverse, nanomolar inhibitors of NQO2 that are functionally active in cells and can modulate NF-kappa B signaling.
Mol.Cancer Ther., 11:194-203, 2012
Cited by
PubMed: 22090421
DOI: 10.1158/1535-7163.MCT-11-0543
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.1901 Å)
Structure validation

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