3TYN

Structure of neuronal nitric oxide synthase heme domain in complex with 2-(((2-(((3S,4S)-4-((6-amino-4-methylpyridin-2-yl)methyl)pyrrolidin-3-yl)oxy)ethyl)amino)methyl)phenol

Summary for 3TYN

Entry DOI	10.2210/pdb3tyn/pdb
Related	3TYL 3TYM 3TYO
Descriptor	Nitric oxide synthase, brain, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ... (7 entities in total)
Functional Keywords	oxidoreductase, nitric oxide synthase, inhibitor binding, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
Biological source	Rattus norvegicus (brown rat,rat,rats)
Cellular location	Cell membrane, sarcolemma ; Peripheral membrane protein : P29476
Total number of polymer chains	2
Total formula weight	100236.94
Authors	Li, H.,Poulos, T.L. (deposition date: 2011-09-26, release date: 2012-03-14, Last modification date: 2023-09-13)
Primary citation	Labby, K.J.,Xue, F.,Kraus, J.M.,Ji, H.,Mataka, J.,Li, H.,Martasek, P.,Roman, L.J.,Poulos, T.L.,Silverman, R.B. Intramolecular hydrogen bonding: A potential strategy for more bioavailable inhibitors of neuronal nitric oxide synthase. Bioorg.Med.Chem., 20:2435-2443, 2012 Cited by PubMed: 22370337 DOI: 10.1016/j.bmc.2012.01.037 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.968 Å)

Structure validation