3TWJ

Rho-associated protein kinase 1 (ROCK 1) IN COMPLEX WITH RKI1447

3TWJ の概要

• エントリーDOI: 10.2210/pdb3twj/pdb
• 分子名称: Rho-associated protein kinase 1, 1-[(3-hydroxyphenyl)methyl]-3-(4-pyridin-4-yl-1,3-thiazol-2-yl)urea, 1,2-ETHANEDIOL, ... (4 entities in total)
• 機能のキーワード: kinase, dimer, dimerization, myosin, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm: Q13464
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 190781.59

構造登録者

Martin, M.P.,Zhu, J.-Y.,Schonbrunn, E. (登録日: 2011-09-21, 公開日: 2012-08-22, 最終更新日: 2023-09-13)

• 主引用文献: Patel, R.A.,Forinash, K.D.,Pireddu, R.,Sun, Y.,Sun, N.,Martin, M.P.,Schonbrunn, E.,Lawrence, N.J.,Sebti, S.M.; RKI-1447 Is a Potent Inhibitor of the Rho-Associated ROCK Kinases with Anti-Invasive and Antitumor Activities in Breast Cancer.; Cancer Res., 72:5025-5034, 2012; PubMed: 22846914; DOI: 10.1158/0008-5472.CAN-12-0954

実験手法

X-RAY DIFFRACTION (2.9 Å)