3TVX

The structure of PDE4A with pentoxifylline at 2.84A resolution

Summary for 3TVX

Entry DOI	10.2210/pdb3tvx/pdb
Descriptor	cAMP-specific 3',5'-cyclic phosphodiesterase 4A, ZINC ION, MAGNESIUM ION, ... (5 entities in total)
Functional Keywords	hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Isoform 1: Cytoplasm, perinuclear region. Isoform 2: Cytoplasm, perinuclear region. Isoform 4: Membrane; Peripheral membrane protein. Isoform 6: Cytoplasm, perinuclear region. Isoform 7: Cytoplasm: P27815
Total number of polymer chains	2
Total formula weight	78472.37
Authors	Badger, J.,Sridhar, V. (deposition date: 2011-09-20, release date: 2012-01-25, Last modification date: 2023-09-13)
Primary citation	Recht, M.I.,Sridhar, V.,Badger, J.,Hernandez, L.,Chie-Leon, B.,Nienaber, V.,Torres, F.E. Fragment-Based Screening for Inhibitors of PDE4A Using Enthalpy Arrays and X-ray Crystallography. J Biomol Screen, 17:469-480, 2012 Cited by PubMed: 22223051 DOI: 10.1177/1087057111430987 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.84 Å)

Structure validation