3TVX

The structure of PDE4A with pentoxifylline at 2.84A resolution

3TVX の概要

• エントリーDOI: 10.2210/pdb3tvx/pdb
• 分子名称: cAMP-specific 3',5'-cyclic phosphodiesterase 4A, ZINC ION, MAGNESIUM ION, ... (5 entities in total)
• 機能のキーワード: hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Isoform 1: Cytoplasm, perinuclear region. Isoform 2: Cytoplasm, perinuclear region. Isoform 4: Membrane; Peripheral membrane protein. Isoform 6: Cytoplasm, perinuclear region. Isoform 7: Cytoplasm: P27815
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 78472.37

構造登録者

Badger, J.,Sridhar, V. (登録日: 2011-09-20, 公開日: 2012-01-25, 最終更新日: 2023-09-13)

• 主引用文献: Recht, M.I.,Sridhar, V.,Badger, J.,Hernandez, L.,Chie-Leon, B.,Nienaber, V.,Torres, F.E.; Fragment-Based Screening for Inhibitors of PDE4A Using Enthalpy Arrays and X-ray Crystallography.; J Biomol Screen, 17:469-480, 2012; PubMed: 22223051; DOI: 10.1177/1087057111430987

実験手法

X-RAY DIFFRACTION (2.84 Å)