3TTP
Structure of multiresistant HIV-1 protease in complex with darunavir
Summary for 3TTP
Entry DOI | 10.2210/pdb3ttp/pdb |
Related | 3ggt 3ggu 3qoz |
Descriptor | HIV-1 protease, (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE, CHLORIDE ION, ... (5 entities in total) |
Functional Keywords | hydrolase, viral praticle, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Human immunodeficiency virus type 1 (HIV-1) |
Total number of polymer chains | 2 |
Total formula weight | 22342.01 |
Authors | Saskova, K.G.,Brynda, J.,Kozisek, M.,Konvalinka, J.,Rezacova, P. (deposition date: 2011-09-15, release date: 2012-09-26, Last modification date: 2023-11-29) |
Primary citation | Kozisek, M.,Lepsik, M.,Grantz Saskova, K.,Brynda, J.,Konvalinka, J.,Rezacova, P. Thermodynamic and structural analysis of HIV protease resistance to darunavir - analysis of heavily mutated patient-derived HIV-1 proteases. Febs J., 281:1834-1847, 2014 Cited by PubMed: 24785545DOI: 10.1111/febs.12743 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.23 Å) |
Structure validation
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