3TT0
Co-structure of Fibroblast Growth Factor Receptor 1 kinase domain with 3-(2,6-dichloro-3,5-dimethoxy-phenyl)-1-{6-[4-(4-ethyl-piperazin-1-yl)-phenylamino]-pyrimidin-4-yl}-1-methyl-urea (BGJ398)
3TT0 の概要
エントリーDOI | 10.2210/pdb3tt0/pdb |
分子名称 | Basic fibroblast growth factor receptor 1, 3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-(6-{[4-(4-ethylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)-1-methylurea, SULFATE ION, ... (5 entities in total) |
機能のキーワード | kinase domain, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
由来する生物種 | Homo sapiens (human) |
細胞内の位置 | Cell membrane; Single-pass type I membrane protein: P11362 |
タンパク質・核酸の鎖数 | 2 |
化学式量合計 | 90377.77 |
構造登録者 | |
主引用文献 | Guagnano, V.,Furet, P.,Spanka, C.,Bordas, V.,Le Douget, M.,Stamm, C.,Brueggen, J.,Jensen, M.R.,Schnell, C.,Schmid, H.,Wartmann, M.,Berghausen, J.,Drueckes, P.,Zimmerlin, A.,Bussiere, D.,Murray, J.,Graus Porta, D. Discovery of 3-(2,6-dichloro-3,5-dimethoxy-phenyl)-1-{6-[4-(4-ethyl-piperazin-1-yl)-phenylamino]-pyrimidin-4-yl}-1-methyl-urea (NVP-BGJ398), a potent and selective inhibitor of the fibroblast growth factor receptor family of receptor tyrosine kinase. J.Med.Chem., 54:7066-7083, 2011 Cited by PubMed: 21936542DOI: 10.1021/jm2006222 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2.8 Å) |
構造検証レポート
検証レポート(詳細版)をダウンロード