3TSH

Crystal structure of Phl p 4, a grass pollen allergen with glucose dehydrogenase activity

Summary for 3TSH

Entry DOI	10.2210/pdb3tsh/pdb
Descriptor	Pollen allergen Phl p 4, DIHYDROFLAVINE-ADENINE DINUCLEOTIDE, SODIUM ION, ... (6 entities in total)
Functional Keywords	flavoprotein, bi-covalent flavinylation, oxidoreductase, glucose dehydrogenase, n-glycosylation, allergy, pollen, allergen, dehydrogenase, grass pollen
Biological source	Phleum pratense (timothy)
Total number of polymer chains	1
Total formula weight	56698.30
Authors	Zafred, D.,Nandy, A.,Keller, W. (deposition date: 2011-09-13, release date: 2012-09-19, Last modification date: 2024-11-06)
Primary citation	Zafred, D.,Nandy, A.,Pump, L.,Kahlert, H.,Keller, W. Crystal structure and immunologic characterization of the major grass pollen allergen Phl p 4. J. Allergy Clin. Immunol., 132:696-703.e10, 2013 Cited by PubMed Abstract: Phl p 4 is a major pollen allergen but exhibits lower allergenicity than other major allergens. The natural protein is glycosylated and shows cross-reactivity with related and structurally unrelated allergens. PubMed: 23683465 DOI: 10.1016/j.jaci.2013.03.021 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation