3TP0

Structural activation of the transcriptional repressor EthR from M. tuberculosis by single amino-acid change mimicking natural and synthetic ligands

Summary for 3TP0

• Entry DOI: 10.2210/pdb3tp0/pdb
• Related: 3TP3
• Descriptor: HTH-type transcriptional regulator EthR, 3-oxo-3-{4-[3-(thiophen-2-yl)-1,2,4-oxadiazol-5-yl]piperidin-1-yl}propanenitrile (3 entities in total)
• Functional Keywords: tetr-family, transcritptional regulatory repressor, dna binding protein, transcription-inhibitor complex, transcription/inhibitor
• Biological source: Mycobacterium tuberculosis
• Total number of polymer chains: 1
• Total formula weight: 24084.06

Authors

Carette, X.,Blondiaux, N.,Willery, E.,Hoos, S.,Lecat-Guillet, N.,Lens, Z.,Wohlkonig, A.,Wintjens, R.,Soror, S.,Fr nois, F.,Diri, B.,Villeret, V.,England, P.,Lippens, G.,Deprez, B.,Locht, C.,Willand, N.,Baulard, A. (deposition date: 2011-09-07, release date: 2011-12-21, Last modification date: 2024-02-28)

• Primary citation: Carette, X.,Blondiaux, N.,Willery, E.,Hoos, S.,Lecat-Guillet, N.,Lens, Z.,Wohlkonig, A.,Wintjens, R.,Soror, S.H.,Frenois, F.,Dirie, B.,Villeret, V.,England, P.,Lippens, G.,Deprez, B.,Locht, C.,Willand, N.,Baulard, A.R.; Structural activation of the transcriptional repressor EthR from Mycobacterium tuberculosis by single amino acid change mimicking natural and synthetic ligands.; Nucleic Acids Res., 40:3018-3030, 2011; PubMed: 22156370; DOI: 10.1093/nar/gkr1113

Experimental method

X-RAY DIFFRACTION (1.9 Å)