3TNW

Structure of CDK2/cyclin A in complex with CAN508

3TNW の概要

• エントリーDOI: 10.2210/pdb3tnw/pdb
• 分子名称: Cyclin-dependent kinase 2, Cyclin-A2, 4-[(E)-(3,5-DIAMINO-1H-PYRAZOL-4-YL)DIAZENYL]PHENOL, ... (5 entities in total)
• 機能のキーワード: cyclin dependent kinase, kinase cyclin, phosphotransferase, cyclin a, phosphorylation at cdk2 threonine 160, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Cytoplasm, cytoskeleton, centrosome: P24941; Nucleus: P30274
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 128920.88

構造登録者

Baumli, S.,Hole, A.J.,Endicott, J.A. (登録日: 2011-09-02, 公開日: 2012-02-15, 最終更新日: 2023-09-13)

• 主引用文献: Baumli, S.,Hole, A.J.,Noble, M.E.,Endicott, J.A.; The CDK9 C-helix Exhibits Conformational Plasticity That May Explain the Selectivity of CAN508.; Acs Chem.Biol., 7:811-816, 2012; PubMed: 22292676; DOI: 10.1021/cb2004516

実験手法

X-RAY DIFFRACTION (2 Å)