3TMK

CRYSTAL STRUCTURE OF YEAST THYMIDYLATE KINASE COMPLEXED WITH THE BISUBSTRATE INHIBITOR TP5A AT 2.0 A RESOLUTION: IMPLICATIONS FOR CATALYSIS AND AZT ACTIVATION

3TMK の概要

• エントリーDOI: 10.2210/pdb3tmk/pdb
• 分子名称: THYMIDYLATE KINASE, P1-(5'-ADENOSYL)P5-(5'-THYMIDYL)PENTAPHOSPHATE (3 entities in total)
• 機能のキーワード: kinase, phosphotransferase
• 由来する生物種: Saccharomyces cerevisiae (baker's yeast)
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 204885.83

構造登録者

Lavie, A.,Schlichting, I.,Konrad, M.,Goody, R.S.,Brundiers, R.,Reinstein, J. (登録日: 1998-01-26, 公開日: 1999-02-16, 最終更新日: 2024-05-22)

• 主引用文献: Lavie, A.,Konrad, M.,Brundiers, R.,Goody, R.S.,Schlichting, I.,Reinstein, J.; Crystal structure of yeast thymidylate kinase complexed with the bisubstrate inhibitor P1-(5'-adenosyl) P5-(5'-thymidyl) pentaphosphate (TP5A) at 2.0 A resolution: implications for catalysis and AZT activation.; Biochemistry, 37:3677-3686, 1998; PubMed: 9521686; DOI: 10.1021/bi9720787

実験手法

X-RAY DIFFRACTION (2 Å)