3TM0

Crystal Structure of 3',5"-Aminoglycoside Phosphotransferase Type IIIa AMPPNP Butirosin A Complex

Replaces:  3H8P

Summary for 3TM0

• Entry DOI: 10.2210/pdb3tm0/pdb
• Related: 1J7I 1J7L 1J7U 1L8T 2B0Q 3TL7
• Descriptor: Aminoglycoside 3'-phosphotransferase, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, (2S)-4-amino-N-[(1R,2S,3R,4R,5S)-5-amino-4-[(2,6-diamino-2,6-dideoxy-alpha-D-glucopyranosyl)oxy]-2-hydroxy-3-(beta-D-xylofuranosyloxy)cyclohexyl]-2-hydroxybutanamide, ... (5 entities in total)
• Functional Keywords: protein kinase, phosphorylation, transferase-antibiotic complex, transferase/antibiotic
• Biological source: Enterococcus faecalis
• Total number of polymer chains: 1
• Total formula weight: 31991.23

Authors

Berghuis, A.M.,Fong, D.H. (deposition date: 2011-08-30, release date: 2011-10-19, Last modification date: 2023-09-13)

• Primary citation: Fong, D.H.,Berghuis, A.M.; Structural basis of APH(3')-IIIa-mediated resistance to N1-substituted aminoglycoside antibiotics.; Antimicrob.Agents Chemother., 53:3049-3055, 2009; PubMed: 19433564; DOI: 10.1128/AAC.00062-09

Experimental method

X-RAY DIFFRACTION (2.1 Å)