3TL9
crystal structure of HIV protease model precursor/Saquinavir complex
Summary for 3TL9
| Entry DOI | 10.2210/pdb3tl9/pdb |
| Related PRD ID | PRD_000454 |
| Descriptor | Protease, (2S)-N-[(2S,3R)-4-[(2S,3S,4aS,8aS)-3-(tert-butylcarbamoyl)-3,4,4a,5,6,7,8,8a-octahydro-1H-isoquinolin-2-yl]-3-hydroxy-1 -phenyl-butan-2-yl]-2-(quinolin-2-ylcarbonylamino)butanediamide, CHLORIDE ION, ... (6 entities in total) |
| Functional Keywords | hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
| Biological source | Human immunodeficiency virus type 1 (HIV-1) |
| Cellular location | Gag-Pol polyprotein: Host cell membrane ; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03367 |
| Total number of polymer chains | 2 |
| Total formula weight | 23329.24 |
| Authors | Agniswamy, J.,Sayer, J.,Weber, I.,Louis, J. (deposition date: 2011-08-29, release date: 2012-04-25, Last modification date: 2023-09-13) |
| Primary citation | Agniswamy, J.,Sayer, J.M.,Weber, I.T.,Louis, J.M. Terminal interface conformations modulate dimer stability prior to amino terminal autoprocessing of HIV-1 protease. Biochemistry, 51:1041-1050, 2012 Cited by PubMed: 22242794DOI: 10.1021/bi201809s PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.32 Å) |
Structure validation
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