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3TKW

Crystal structure of HIV protease model precursor/Darunavir complex

Summary for 3TKW
Entry DOI10.2210/pdb3tkw/pdb
DescriptorProtease, CHLORIDE ION, SODIUM ION, ... (6 entities in total)
Functional Keywordshydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceHuman immunodeficiency virus type 1 (HIV-1)
Cellular locationGag-Pol polyprotein: Host cell membrane ; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03367
Total number of polymer chains2
Total formula weight23333.61
Authors
Agniswamy, J.,Sayer, J.,Weber, I.,Louis, J. (deposition date: 2011-08-29, release date: 2012-04-25, Last modification date: 2023-09-13)
Primary citationAgniswamy, J.,Sayer, J.M.,Weber, I.T.,Louis, J.M.
Terminal interface conformations modulate dimer stability prior to amino terminal autoprocessing of HIV-1 protease.
Biochemistry, 51:1041-1050, 2012
Cited by
PubMed: 22242794
DOI: 10.1021/bi201809s
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.55 Å)
Structure validation

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