3TKH
Crystal structure of Chk1 in complex with inhibitor S01
Summary for 3TKH
Entry DOI | 10.2210/pdb3tkh/pdb |
Descriptor | Serine/threonine-protein kinase Chk1, SULFATE ION, 1-(morpholin-4-yl)-2-[4-(2-{[5-(pyridin-3-yl)-1,3-thiazol-2-yl]amino}pyridin-4-yl)piperazin-1-yl]ethanone, ... (4 entities in total) |
Functional Keywords | chk1, kinase, cell checkpoint, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus: O14757 |
Total number of polymer chains | 1 |
Total formula weight | 37483.79 |
Authors | |
Primary citation | Dudkin, V.Y.,Rickert, K.,Kreatsoulas, C.,Wang, C.,Arrington, K.L.,Fraley, M.E.,Hartman, G.D.,Yan, Y.,Ikuta, M.,Stirdivant, S.M.,Drakas, R.A.,Walsh, E.S.,Hamilton, K.,Buser, C.A.,Lobell, R.B.,Sepp-Lorenzino, L. Pyridyl aminothiazoles as potent inhibitors of Chk1 with slow dissociation rates. Bioorg.Med.Chem.Lett., 22:2609-2612, 2012 Cited by PubMed: 22374217DOI: 10.1016/j.bmcl.2012.01.110 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.79 Å) |
Structure validation
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