3TKC

Design, Synthesis, Evaluation and Structure of Vitamin D Analogues with Furan Side Chains

Summary for 3TKC

• Entry DOI: 10.2210/pdb3tkc/pdb
• Related: 3A3Z 3A40
• Descriptor: Vitamin D3 receptor, (1S,3R,5Z,7E,14beta,17alpha,20S)-20-[5-(1-hydroxy-1-methylethyl)furan-2-yl]-9,10-secopregna-5,7,10-triene-1,3-diol, SULFATE ION, ... (4 entities in total)
• Functional Keywords: alpha-helical sandwich, transcription, calcitriol, phosphorylation, nucleus
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus: P11473
• Total number of polymer chains: 1
• Total formula weight: 30024.61

Authors

Huet, T.,Moras, D.,Rochel, N. (deposition date: 2011-08-26, release date: 2012-03-07, Last modification date: 2023-09-13)

• Primary citation: Fraga, R.,Zacconi, F.,Sussman, F.,Ordonez-Moran, P.,Munoz, A.,Huet, T.,Molnar, F.,Moras, D.,Rochel, N.,Maestro, M.,Mourino, A.; Design, synthesis, evaluation, and structure of vitamin D analogues with furan side chains.; Chemistry, 18:603-612, 2012; PubMed: 22162241; DOI: 10.1002/chem.201102695

Experimental method

X-RAY DIFFRACTION (1.75 Å)