3TKC

Design, Synthesis, Evaluation and Structure of Vitamin D Analogues with Furan Side Chains

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0004879	molecular_function	nuclear receptor activity
A	0006355	biological_process	regulation of DNA-templated transcription

Functional Information from PDB Data

site_id	AC1
Number of Residues	14
Details	BINDING SITE FOR RESIDUE FMV A 1

Chain	Residue
A	TYR143
A	TRP286
A	CYS288
A	VAL300
A	HIS305
A	HIS397
A	LEU227
A	VAL234
A	SER237
A	ILE268
A	ILE271
A	ARG274
A	SER275
A	SER278

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 428

Chain	Residue
A	THR280
A	MET281
A	LYS321
A	HOH556

---

site_id	AC3
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 A 2

Chain	Residue
A	HOH54
A	HOH175
A	HOH178
A	PRO408
A	GLU409
A	CYS410
A	SER411
A	HOH522

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	18
Details	Region: {"description":"Interaction with coactivator LXXLL motif","evidences":[{"source":"UniProtKB","id":"P13053","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10678179","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11344298","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1DB1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1IE8","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10678179","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11344298","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1DB1","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10678179","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11344298","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1IE8","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI5
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10678179","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11344298","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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