3TJM

Crystal Structure of the Human Fatty Acid Synthase Thioesterase Domain with an Activate Site-Specific Polyunsaturated Fatty Acyl Adduct

3TJM の概要

• エントリーDOI: 10.2210/pdb3tjm/pdb
• 分子名称: Fatty acid synthase, methyl (R)-(6Z,9Z,12Z)-octadeca-6,9,12-trien-1-ylphosphonofluoridate (3 entities in total)
• 機能のキーワード: thioesterase domain, fatty acid synthesis, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 31315.49

構造登録者

Zhang, W.,Zheng, F.,Florante, A.Q. (登録日: 2011-08-24, 公開日: 2011-09-28, 最終更新日: 2023-09-13)

• 主引用文献: Zhang, W.,Chakravarty, B.,Zheng, F.,Gu, Z.,Wu, H.,Mao, J.,Wakil, S.J.,Quiocho, F.A.; Crystal structure of FAS thioesterase domain with polyunsaturated fatty acyl adduct and inhibition by dihomo-gamma-linolenic acid.; Proc.Natl.Acad.Sci.USA, 108:15757-15762, 2011; PubMed: 21908709; DOI: 10.1073/pnas.1112334108

実験手法

X-RAY DIFFRACTION (1.48 Å)