3TJE

Crystal structure of Fas receptor extracellular domain in complex with Fab E09

3TJE の概要

• エントリーDOI: 10.2210/pdb3tje/pdb
• 関連するPDBエントリー: 3THM
• 分子名称: Fab E09, light chain, Fab E09, heavy chain, Tumor necrosis factor receptor superfamily member 6, ... (7 entities in total)
• 機能のキーワード: agonistic antibody, fab fragment, antibody-receptor complex, tumor necrosis factor receptor, cysteine-rich domain, fas, immune system
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted. Isoform 3: Secreted. Isoform 4: Secreted. Isoform 5: Secreted. Isoform 6: Secreted: P25445
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 67221.12

構造登録者

Zuger, S.,Stirnimann, C.,Briand, C.,Grutter, M.G. (登録日: 2011-08-24, 公開日: 2012-05-09, 最終更新日: 2023-09-13)

• 主引用文献: Chodorge, M.,Zuger, S.,Stirnimann, C.,Briand, C.,Jermutus, L.,Grutter, M.G.,Minter, R.R.; A series of Fas receptor agonist antibodies that demonstrate an inverse correlation between affinity and potency.; Cell Death Differ., 19:1187-1195, 2012; PubMed: 22261618; DOI: 10.1038/cdd.2011.208

実験手法

X-RAY DIFFRACTION (1.93 Å)