3TI1

CDK2 in complex with SUNITINIB

Summary for 3TI1

• Entry DOI: 10.2210/pdb3ti1/pdb
• Related: 3TIY 3TIZ
• Descriptor: Cyclin-dependent kinase 2, N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carbo xamide, 1,2-ETHANEDIOL, ... (4 entities in total)
• Functional Keywords: protein kinase, allosteric ligand, sunitinib, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm, cytoskeleton, centrosome: P24941
• Total number of polymer chains: 1
• Total formula weight: 34871.51

Authors

Alam, R.,Schonbrunn, E. (deposition date: 2011-08-19, release date: 2012-08-22, Last modification date: 2023-09-13)

• Primary citation: Martin, M.P.,Alam, R.,Betzi, S.,Ingles, D.J.,Zhu, J.Y.,Schonbrunn, E.; A Novel Approach to the Discovery of Small-Molecule Ligands of CDK2.; Chembiochem, 13:2128-2136, 2012; PubMed: 22893598; DOI: 10.1002/cbic.201200316

Experimental method

X-RAY DIFFRACTION (1.99 Å)