3TFR

Ternary complex structure of DNA polymerase beta with a gapped DNA substrate and a, b dAMP(CF2)PP in the active site

Summary for 3TFR

• Entry DOI: 10.2210/pdb3tfr/pdb
• Related: 3TFS
• Descriptor: DNA polymerase beta, DNA (5'-D(*CP*CP*GP*AP*CP*TP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*C)-3'), ... (9 entities in total)
• Functional Keywords: dna polymerase, stereoselectivity, transferase-dna complex, transferase/dna
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus: P06746
• Total number of polymer chains: 4
• Total formula weight: 48444.45

Authors

Chamberlain, B.T.,Batra, V.K.,Beard, W.A.,Kadina, A.P.,Shock, D.D.,Kashemirov, B.A.,McKenna, C.E.,Goodman, M.F.,Wilson, S.H. (deposition date: 2011-08-16, release date: 2012-03-21, Last modification date: 2023-09-13)

• Primary citation: Chamberlain, B.T.,Batra, V.K.,Beard, W.A.,Kadina, A.P.,Shock, D.D.,Kashemirov, B.A.,McKenna, C.E.,Goodman, M.F.,Wilson, S.H.; Stereospecific Formation of a Ternary Complex of (S)-alpha, beta-Fluoromethylene-dATP with DNA Pol beta.; Chembiochem, 13:528-530, 2012; PubMed: 22315190; DOI: 10.1002/cbic.201100738

Experimental method

X-RAY DIFFRACTION (2 Å)