3TD8

Structural Analysis of Pneumocystis carinii Dihydrofolate Reductase Complex with NADPH and 2,4-diamino-5-methyl-6-[2'-(4-carboxy-1-pentynyl)-5'-methoxybenzyl]pyrido[2,3-d]pyrimidine

3TD8 の概要

• エントリーDOI: 10.2210/pdb3td8/pdb
• 関連するPDBエントリー: 3cd2
• 分子名称: Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 6-{2-[(2,4-diamino-5-methylpyrido[2,3-d]pyrimidin-6-yl)methyl]-4-methoxyphenyl}hex-5-ynoic acid, ... (4 entities in total)
• 機能のキーワード: dihydrofolate reductase, oxidoreductase
• 由来する生物種: Pneumocystis carinii
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 25069.41

構造登録者

Cody, V.,Pace, J.,Stewart, E. (登録日: 2011-08-10, 公開日: 2012-04-11, 最終更新日: 2023-09-13)

• 主引用文献: Cody, V.,Pace, J.,Stewart, E.; Structural analysis of Pneumocystis cariniidihydrofolate reductase complexed with NADPH and 2,4-diamino-6-[2-(5-carboxypent-1-yn-1-yl)-5-methoxybenzyl]-5-methylpyrido[2,3-d]pyrimidine.; Acta Crystallogr.,Sect.F, 68:418-423, 2012; PubMed: 22505410; DOI: 10.1107/S1744309112008688

実験手法

X-RAY DIFFRACTION (1.8 Å)