3TD1

Crystal structure of the bacterial A1408G-mutant and the protozoa cytoplasmic ribosomal decoding site in complex with geneticin

Summary for 3TD1

• Entry DOI: 10.2210/pdb3td1/pdb
• Related: 1MWL 3TD0
• Descriptor: RNA (5'-R(*UP*UP*GP*CP*GP*UP*CP*GP*CP*GP*(5BU)P*CP*GP*AP*CP*GP*AP*AP*GP*UP*CP*GP*C)-3'), GENETICIN (3 entities in total)
• Functional Keywords: decoding, ribosome, rna-antibiotic complex, rna/antibiotic
• Total number of polymer chains: 2
• Total formula weight: 15893.71

Authors

Kondo, J. (deposition date: 2011-08-10, release date: 2011-12-07, Last modification date: 2023-11-01)

Primary citation

Kondo, J.
A structural basis for the antibiotic resistance conferred by an A1408G mutation in 16S rRNA and for the antiprotozoal activity of aminoglycosides
Angew.Chem.Int.Ed.Engl., 51:465-468, 2012

PubMed Abstract: Resistance explained: The crystal structures of the ribosomal decoding A site with an A1408G antibiotic-resistance mutation were solved in the presence and absence of the aminoglycoside geneticin (see structure, geneticin carbon framework in yellow). These structures show how bacteria acquire high-level resistance against aminoglycosides by the mutation.

PubMed: 22110016
DOI: 10.1002/anie.201106084

Experimental method

X-RAY DIFFRACTION (2.1 Å)