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3TCP

Crystal structure of the catalytic domain of the proto-oncogene tyrosine-protein kinase MER in complex with inhibitor UNC569

Summary for 3TCP
Entry DOI10.2210/pdb3tcp/pdb
Related2BRB 2POC 3BPR
DescriptorTyrosine-protein kinase Mer, 1-[(trans-4-aminocyclohexyl)methyl]-N-butyl-3-(4-fluorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-6-amine, CHLORIDE ION, ... (5 entities in total)
Functional Keywordstyrosine kinase, acute lymphoblastic leukemia, rational structure-based drug design, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceHomo sapiens (human)
Cellular locationMembrane ; Single-pass type I membrane protein : Q12866
Total number of polymer chains2
Total formula weight72798.47
Authors
Primary citationLiu, J.,Yang, C.,Simpson, C.,Deryckere, D.,Van Deusen, A.,Miley, M.J.,Kireev, D.,Norris-Drouin, J.,Sather, S.,Hunter, D.,Korboukh, V.K.,Patel, H.S.,Janzen, W.P.,Machius, M.,Johnson, G.L.,Earp, H.S.,Graham, D.K.,Frye, S.V.,Wang, X.
Discovery of Novel Small Molecule Mer Kinase Inhibitors for the Treatment of Pediatric Acute Lymphoblastic Leukemia.
ACS Med Chem Lett, 3:129-134, 2012
Cited by
PubMed: 22662287
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.69 Å)
Structure validation

217705

건을2024-03-27부터공개중

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