3TBG
Human cytochrome P450 2D6 with two thioridazines bound in active site
Summary for 3TBG
Entry DOI | 10.2210/pdb3tbg/pdb |
Related | 3QM4 |
Descriptor | Cytochrome P450 2D6, 10-{2-[(2R)-1-methylpiperidin-2-yl]ethyl}-2-(methylsulfanyl)-10H-phenothiazine, ZINC ION, ... (7 entities in total) |
Functional Keywords | cytochrome p450, monooxygenase, thioridazine, oxidoreductase |
Biological source | Homo sapiens (human) |
Cellular location | Endoplasmic reticulum membrane; Peripheral membrane protein: P10635 |
Total number of polymer chains | 4 |
Total formula weight | 221550.30 |
Authors | Wang, A.,Stout, C.D.,Johnson, E.F. (deposition date: 2011-08-05, release date: 2012-08-08, Last modification date: 2023-09-13) |
Primary citation | Wang, A.,Stout, C.D.,Zhang, Q.,Johnson, E.F. Contributions of Ionic Interactions and Protein Dynamics to Cytochrome P450 2D6 (CYP2D6) Substrate and Inhibitor Binding. J.Biol.Chem., 290:5092-5104, 2015 Cited by PubMed: 25555909DOI: 10.1074/jbc.M114.627661 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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