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3TBG

Human cytochrome P450 2D6 with two thioridazines bound in active site

Summary for 3TBG
Entry DOI10.2210/pdb3tbg/pdb
Related3QM4
DescriptorCytochrome P450 2D6, 10-{2-[(2R)-1-methylpiperidin-2-yl]ethyl}-2-(methylsulfanyl)-10H-phenothiazine, ZINC ION, ... (7 entities in total)
Functional Keywordscytochrome p450, monooxygenase, thioridazine, oxidoreductase
Biological sourceHomo sapiens (human)
Cellular locationEndoplasmic reticulum membrane; Peripheral membrane protein: P10635
Total number of polymer chains4
Total formula weight221550.30
Authors
Wang, A.,Stout, C.D.,Johnson, E.F. (deposition date: 2011-08-05, release date: 2012-08-08, Last modification date: 2023-09-13)
Primary citationWang, A.,Stout, C.D.,Zhang, Q.,Johnson, E.F.
Contributions of Ionic Interactions and Protein Dynamics to Cytochrome P450 2D6 (CYP2D6) Substrate and Inhibitor Binding.
J.Biol.Chem., 290:5092-5104, 2015
Cited by
PubMed: 25555909
DOI: 10.1074/jbc.M114.627661
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.1 Å)
Structure validation

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