3T8S

Apo and InsP3-bound Crystal Structures of the Ligand-Binding Domain of an InsP3 Receptor

3T8S の概要

• エントリーDOI: 10.2210/pdb3t8s/pdb
• 分子名称: Inositol 1,4,5-trisphosphate receptor type 1, D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE (2 entities in total)
• 機能のキーワード: beta-trefoil fold, armadillo repeat fold, ligand-binding domain, ligand(ip3)-binding, ip3, endoplasmic reticulum, ligand gated channel, ca2+ release channel, transport protein, membrane protein
• 由来する生物種: Rattus norvegicus (brown rat,rat,rats)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 132612.00

構造登録者

Lin, C.,Baek, K.,Lu, Z. (登録日: 2011-08-01, 公開日: 2011-09-07, 最終更新日: 2023-09-13)

主引用文献

Lin, C.C.,Baek, K.,Lu, Z.
Apo and InsP(3)-bound crystal structures of the ligand-binding domain of an InsP(3) receptor.
Nat.Struct.Mol.Biol., 18:1172-1174, 2011

PubMed Abstract: We report the crystal structures of the ligand-binding domain (LBD) of a rat inositol 1,4,5-trisphosphate receptor (InsP(3)R) in its apo and InsP(3)-bound conformations. Comparison of these two conformations reveals that LBD's first β-trefoil fold (β-TF1) and armadillo repeat fold (ARF) move together as a unit relative to its second β-trefoil fold (β-TF2). Whereas apo LBD may spontaneously transition between gating conformations, InsP(3) binding shifts this equilibrium toward the active state.

PubMed: 21892169
DOI: 10.1038/nsmb.2112

実験手法

X-RAY DIFFRACTION (3.77 Å)