3T6B
Structure of human DPPIII in complex with the opioid peptide Tynorphin, at 2.4 Angstroms
Summary for 3T6B
Entry DOI | 10.2210/pdb3t6b/pdb |
Related | 3T6J |
Descriptor | Dipeptidyl peptidase 3, Tynorphin (3 entities in total) |
Functional Keywords | human dipeptidylpeptidase iii, entropy binding, opioid peptide complex, domain motion, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) More |
Cellular location | Cytoplasm: Q9NY33 |
Total number of polymer chains | 4 |
Total formula weight | 164539.13 |
Authors | Bezerra, G.A.,Gruber, K. (deposition date: 2011-07-28, release date: 2012-04-04, Last modification date: 2023-11-01) |
Primary citation | Bezerra, G.A.,Dobrovetsky, E.,Viertlmayr, R.,Dong, A.,Binter, A.,Abramic, M.,Macheroux, P.,Dhe-Paganon, S.,Gruber, K. Entropy-driven binding of opioid peptides induces a large domain motion in human dipeptidyl peptidase III Proc.Natl.Acad.Sci.USA, 109:6525-6530, 2012 Cited by PubMed: 22493238DOI: 10.1073/pnas.1118005109 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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