3T5O

Crystal Structure of human Complement Component C6

3T5O の概要

• エントリーDOI: 10.2210/pdb3t5o/pdb
• 分子名称: Complement component C6, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-glucopyranose-(1-3)-alpha-L-fucopyranose, ... (6 entities in total)
• 機能のキーワード: macpf, mac, membrane attack complex, complement, innate immune system, blood, membrane, c7, c8, c9, cytolysin, immune system
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Secreted: P13671
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 104289.20

構造登録者

Aleshin, A.E.,Stec, B.,Bankston, L.A.,DiScipio, R.G.,Liddington, R.C. (登録日: 2011-07-27, 公開日: 2012-02-01, 最終更新日: 2020-07-29)

• 主引用文献: Aleshin, A.E.,Schraufstatter, I.U.,Stec, B.,Bankston, L.A.,Liddington, R.C.,Discipio, R.G.; Structure of Complement C6 Suggests a Mechanism for Initiation and Unidirectional, Sequential Assembly of Membrane Attack Complex (MAC).; J.Biol.Chem., 287:10210-10222, 2012; PubMed: 22267737; DOI: 10.1074/jbc.M111.327809

実験手法

X-RAY DIFFRACTION (2.869 Å)